Job Description

Revolution Medicines seeks a process chemist to develop and optimize synthetic routes for small-molecule oncology drugs. The role involves independent experimental design, reaction optimization, scale-up planning, and technology transfer to manufacturing partners in a hands-on laboratory setting.

Responsibilities

• Own development of reactions and process workstreams, setting experimental approaches and coordinating work
• Design and execute experiments to evaluate alternative synthetic routes and optimize reaction conditions
• Investigate reaction behavior and impurity formation using mechanistic reasoning and literature review
• Develop robust manufacturing processes by defining parameter sensitivity, reproducibility, and impurity control
• Prepare technology transfer procedures and work with CDMOs to resolve implementation issues

Requirements

• PhD in organic chemistry with at least 2 years of related experience
• Demonstrated ability to independently design and execute process development studies
• Strong hands-on skills in multistep synthesis, reaction optimization, and characterization techniques
• Experience connecting experimental results to process robustness and scale-up considerations
• Proven track record taking responsibility for defined scientific workstreams
• Clear scientific writing and proficiency with electronic laboratory notebooks and ChemDraw

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